Preferred Label : SHR, Rat Strain;
NCIt synonyms : SHR Rat Strain;
NCIt related terms : SHR;
NCIt definition : SHR: rats develop hypertension spontaneously without exception at the age of 7-15
weeks. There is a systolic blood pressure plateau of about 200 mmHg. The genetic basis
is polygenic, with at least three major genes involved (Tanase and Suzuki 1971, Yen
et al 1974). There is a high incidence of cardiovascular disease (Okamoto et al 1973),
but a low incidence of stroke which can be increased to about 30% with chronic stress
(Yamori 1984).;
Alternative definition : CDISC: The spontaneous hypertensive rat was derived by Okamoto at the Kyoto school
of medicine (1963) from a cross between an outbred Wistar Kyoto male with a significant
elevation of blood pressure and a female Wistar Kyoto with elevated blood pressure.
SHR rats develop hypertension spontaneously without exception at the age of 7-15 weeks
with a systolic blood pressure plateau of about 200 mmHg. The genetic basis is polygenic,
with at least three major genes involved (Tanase and Suzuki 1971, Yen et al 1974).;
Origin ID : C14412;
UMLS CUI : C1519142;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
