Carzelesin - CISMeF

Preferred Label : Carzelesin;

NCIt synonyms : 2-Benzofurancarboxamide, N-(2-((1-(chloromethyl)-1,6-dihydro-8-methyl-5-(((phenylamino)carbonyl)oxy)benzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)-1H-indol-5-yl)-6-(diethylamino)-, (S)-;

NCIt definition : A cyclopropylpyrroloindole prodrug analogue and DNA minor groove binding agent, with antineoplastic activity. After hydrolysis, the cyclopropyl group of carzelesin alkylates N3-adenine in a sequence-selective fashion. This results in tumor growth inhibition.;

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called alkylating agents.;

UNII : 668UF07O1P;

InChIKey : BBZDXMBRAFTCAA-AREMUKBSSA-N;

CAS number : 119813-10-4;

Molecule name : U-80244;

Chemical formula : C41H37ClN6O5;

NSC code : 619029;

Codes from synonyms : NSC0619029; CDR0000045515;

Details

Origin ID

C1441;

UMLS CUI

C0172048;

Currated CISMeF NLP mapping
- carzelesin [MeSH concept]
- carzelesin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- carzelesin [MeSH concept]
- carzelesin [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients