Preferred Label : eVLP CMV gB-pp65 Plus GM-CSF VBI-1901;
NCIt synonyms : VBI-1901 Vaccine; Enveloped Virus-like Particles CMV gB-pp65 Plus GM-CSF VBI-1901;
NCIt definition : A cancer vaccine composed of enveloped virus-like particles (eVLPs) containing the
human cytomegalovirus (CMV) antigens glycoprotein B (gB) and phosphoprotein 65 (pp65;
UL83) that are combined with the immunoadjuvant granulocyte-macrophage colony-stimulating
factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon
intradermal administration of VBI-1901, the eVLPs are taken up by and activate immune
cells, such as dendritic cells (DCs), thereby stimulating the immune system to exert
a cytotoxic T-lymphocyte (CTL) immune response against CMV gB and pp65-expressing
tumor cells. This may lyse and inhibit the proliferation of CMV-infected cancer cells.
eVLPs, derived from viral structural proteins, stimulate the immune system and promote
CTL responses. CMV gB and pp65 are expressed in certain tumor cell types, such as
glioblastoma multiforme (GBM). GM-CSF stimulates the immune system and potentiates
the antitumor immune response.;
Molecule name : VBI 1901; VBI-1901;
NCI Metathesaurus CUI : CL542158;
Origin ID : C143956;
UMLS CUI : C4685004;
Semantic type(s)
- concept_is_in_subset
- has_target
