Troxacitabine - CISMeF

Preferred Label : Troxacitabine;

NCIt synonyms : 2(1H)-Pyrimidinone, 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-;

NCIt definition : A dioxolane derivative and a novel L-configuration deoxycytidine analogue with potent antineoplastic activity. When incorporated into growing chain during DNA replication, troxacitabine stops DNA polymerization due to its unnatural L-configuration, in contrast to the normal nucleotides with D-configuration. As a result, this agent terminates DNA synthesis upon incorporated into DNA molecules, and consequently interrupts tumor cell proliferation.;

Alternative definition : NCI-GLOSS: A drug being studied for use as an anticancer agent.;

UNII : 60KQZ0388Y;

InChIKey : RXRGZNYSEHTMHC-BQBZGAKWSA-N;

CAS number : 145918-75-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 145918-75-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Troxatyl;

Molecule name : L-Oddc; BCH-4556;

Chemical formula : C8H11N3O4;

Codes from synonyms : CDR0000046760;

Details

Origin ID

C1438;

UMLS CUI

C0877874;

Currated CISMeF NLP mapping
- troxacitabine [MeSH concept]
- troxacitabine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- troxacitabine [MeSH concept]
- troxacitabine [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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