" /> Lobaplatin - CISMeF





Preferred Label : Lobaplatin;

NCIt synonyms : 1,2-diammino-methy lcyclobutane-platinum (II) lactate;

NCIt definition : A third-generation, water-soluble platinum compound with potential antineoplastic activity. Lobaplatin forms highly reactive, charged, platinum complexes that bind to nucleophilic groups such as GC- and AG-rich sites in DNA, inducing intrastrand DNA cross-links. These cross-links will ultimately result in induction of apoptosis and cell growth inhibition. Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.;

Alternative definition : NCI-GLOSS: A substance that contains the metal platinum and may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent.;

UNII : OX5XK1JD8C;

InChIKey : RLXPIABKJFUYFG-DOYDWZMXSA-M;

CAS number : 135558-11-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 135558-11-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : D-19466;

Chemical formula : C6H14N2.C3H4O3.Pt;

Codes from synonyms : CDR0000045385; 310;

PubMed : 21034513;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
12/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.