Nolatrexed - CISMeF

Preferred Label : Nolatrexed;

NCIt synonyms : 2-Amino-6-methyl-5-(4-pyridylthio)-4(3H)-quinazolinone;

NCIt definition : A water-soluble lipophilic quinazoline folate analog, with antineoplastic activity. Upon administration, nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. Nolatrexed also exhibits radiosensitizing activity.;

UNII : K75ZUN743Q;

InChIKey : XHWRWCSCBDLOLM-UHFFFAOYSA-N;

CAS number : 147149-76-6;

NCI Metathesaurus CUI : CL541560;

Codes from synonyms : 358;

Details

Origin ID

C143088;

UMLS CUI

C0796399;

Automatic exact mappings (from CISMeF team)
- nolatrexed [MeSH concept]
- nolatrexed [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- nolatrexed [MeSH Supplementary Concept]
- nolatrexed [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Nolatrexed Dihydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Nolatrexed Dihydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients