" /> Nolatrexed - CISMeF





Preferred Label : Nolatrexed;

NCIt synonyms : 2-Amino-6-methyl-5-(4-pyridylthio)-4(3H)-quinazolinone;

NCIt definition : A water-soluble lipophilic quinazoline folate analog, with antineoplastic activity. Upon administration, nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. Nolatrexed also exhibits radiosensitizing activity.;

UNII : K75ZUN743Q;

InChIKey : XHWRWCSCBDLOLM-UHFFFAOYSA-N;

CAS number : 147149-76-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 147149-76-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

NCI Metathesaurus CUI : CL541560;

Codes from synonyms : 358;

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Keyword's position in hierarchy(ies) : arborescence

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29/05/2024


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