CpG Oligodeoxynucleotide TLR9 Agonist DV281

Preferred Label : CpG Oligodeoxynucleotide TLR9 Agonist DV281;

NCIt synonyms : TLR9 Agonist DV281; CPG ODN TLR9 Agonist DV281;

NCIt related terms : DV-281;

NCIt definition : A proprietary synthetic, aerosolized C-class CpG oligodeoxynucleotide-based (ODN) agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity. Upon inhalation, CpG ODN TLR9 agonist DV281 specifically targets, binds to and activates TLR9 expressed by plasmacytoid dendritic cells (pDCs) and B-cells. This initiates immune signaling pathways and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against antigens expressed by lung cancer cells. TLR9, a member of the TLR family, plays a fundamental role in pathogen recognition and activation of the innate immune system.;

UNII : 4LOR72V17G;

Molecule name : DV 281; DV-281;

NCI Metathesaurus CUI : CL541395;

Details

Origin ID

C143006;

UMLS CUI

C4684947;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DV281 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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