" /> Bedaquiline Fumarate - CISMeF





Preferred Label : Bedaquiline Fumarate;

NCIt synonyms : BDQ Fumarate;

NCIt related terms : Sirturo;

NCIt definition : The fumarate salt form of bedaquiline, an orally bioavailable diarylquinoline antimycobacterial agent, that can be used in the treatment of pulmonary multi-drug resistant tuberculosis (MDR-TB). Upon oral administration, bedaquiline specifically binds to subunit c of Mycobacterium tuberculosis (M. tuberculosis) adenosine 5'-triphosphate (ATP) synthase, thereby preventing ATP synthase activity. This inhibits ATP synthesis in M. tuberculosis, thereby blocking its energy metabolism and killing M. tuberculosis.;

UNII : P04QX2C1A5;

InChIKey : ZLVSPMRFRHMMOY-WWCCMVHESA-N;

CAS number : 845533-86-0;

Drug name : Sirturo;

Molecule name : R403323;

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29/07/2025


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