Avatrombopag Maleate

Preferred Label : Avatrombopag Maleate;

NCIt synonyms : 4-Piperidinecarboxylic Acid, 1-(3-Chloro-5-(((4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1- piperazinyl)-2-thiazolyl)amino)carbonyl)-2-pyridinyl)-, (2Z)-2-butenedioate (1:1); E5501 Maleate; 1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2- yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid mono-(2Z)-but-2-enedioate;

NCIt definition : The maleate salt form of avatrombopag, an orally available platelet thrombopoietin receptor (TPOR; MPL) agonist, with potential megakaryopoiesis stimulating activity. Upon administration, avatrombopag binds to and stimulates TPOR, which may lead to the proliferation and differentiation of megakaryocytes from bone marrow progenitor cells. This increases the production of platelets and may prevent chemotherapy-induced thrombocytopenia (CIT). TPOR is a cytokine receptor and member of the hematopoietin receptor superfamily.;

UNII : GDW7M2P1IS;

InChIKey : MISPBGHDNZYFNM-BTJKTKAUSA-N;

CAS number : 677007-74-8;

NCI Metathesaurus CUI : CL541337;

Details

Origin ID

C142941;

UMLS CUI

C4684922;

Currated CISMeF NLP mapping
- Avatrombopag maleate (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Avatrombopag maleate (substance) [SNOMED CT concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Avatrombopag [NCIt concept]
is_salt_form_of
- Avatrombopag [NCIt concept]

Keyword's position in hierarchy(ies) :

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