Preferred Label : Numidargistat;
NCIt synonyms : Arginase Inhibitor INCB001158;
NCIt definition : An orally available inhibitor of arginase, a manganese-dependent enzyme that hydrolyzes
the amino acid arginine to form ornithine and urea, with potential immunomodulating
and antineoplastic activities. Upon administration, numidargistat inhibits the breakdown
of arginine by arginase, which is produced by myeloid cells, and restores arginine
levels. This allows arginine to stimulate the synthesis of nitric oxide and the secretion
of pro-inflammatory cytokines and chemokines, which induces the proliferation and
activation of T-cells. Therefore, this agent may prevent the immunosuppressive effects
of tumor-infiltrating myeloid cells and promote lymphocyte-mediated immune responses
against tumor cells. Arginase is produced by neutrophils, macrophages and myeloid-derived
suppressor cells (MDSC) and plays a role in inflammation-associated immunosuppression.;
UNII : IFD73D535A;
InChIKey : ZZJLMZYUGLJBSO-LAEOZQHASA-N;
CAS number : 2095732-06-0;
Molecule name : INCB001158; CB-1158;
NCI Metathesaurus CUI : CL540753;
Origin ID : C142866;
UMLS CUI : C5446315;
Semantic type(s)
- concept_is_in_subset
