Preferred Label : Troriluzole;
NCIt synonyms : Glycinamide, Glycylglycyl-N2-methyl-N-(6-(trifluoromethoxy)-2-benzothiazolyl)-; Trigriluzole;
NCIt definition : A formulation comprised of a prodrug form of the benzothiazole derivative riluzole,
with potential anti-depressant, anxiolytic and antineoplastic activities. Following
oral administration, troriluzole is converted into the active form riluzole. While
the mechanism of action of riluzole is unknown, its pharmacological activities, some
of which may be related to its effect, include the following: 1) an inhibitory effect
on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3)
interference with intracellular events that follow transmitter binding at excitatory
amino acid receptors. These activities may result in myorelaxation and sedation due
to the blockade of glutamatergic neurotransmission. Additionally, these activities
may result in the inhibition of enzymes that are necessary for cell growth, which
may decrease tumor cell growth and metastasis.;
UNII : S7H48S6K7H;
InChIKey : YBZSGIWIPOUSHY-UHFFFAOYSA-N;
CAS number : 1926203-09-9;
Molecule name : BHV 4157; BHV-4157;
NCI Metathesaurus CUI : CL540756;
Origin ID : C142847;
UMLS CUI : C5139823;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
