NCIt definition : A humanized monoclonal antibody directed against cell cycle associated protein 1 (cytoplasmic
activation- and proliferation-associated protein 1; Caprin-1; CAPRIN1; RNA granule
protein 105; RNG105), with potential antineoplastic activity. Upon administration,
anti-Caprin-1 monoclonal antibody TRK-950 targets and binds to Caprin-1 expressed
on tumor cells. This may induce antibody-dependent cell-mediated cytotoxicity (ADCC)
and antibody-dependent cellular phagocytosis (ADCP), thereby killing Caprin-1-expressing
tumor cells. Caprin-1 is overexpressed on certain tumor cell types and plays a key
role in tumor cell proliferation and metastasis.;
Semantic type(s)