Preferred Label : Zigakibart;
NCIt synonyms : Anti-TNFSF13 Monoclonal Antibody BION-1301; Anti-A PRoliferation-Inducing Ligand Monoclonal Antibody BION-1301; Anti-APRIL Monoclonal Antibody BION-1301;
NCIt definition : A humanized monoclonal antibody targeting a proliferation-inducing ligand (APRIL;
tumor necrosis factor ligand superfamily member 13; TNFSF13), with potential antineoplastic
and immune checkpoint inhibitory activities. Upon administration, zigakibart binds
to APRIL and inhibits its binding to both of its receptors, B-cell maturation antigen
(BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and transmembrane
activator and CAML Interactor (TACI; tumor necrosis factor receptor superfamily member
13B; TNFRSF13B). This inhibits the activation of both BCMA and TACI, and their downstream
signaling pathways, which prevents tumor growth, tumor cell adhesion to bone marrow
cells and immune suppression. Additionally, zigakibart may reduce APRIL-induced drug
resistance which occurs in some tumors. APRIL, an extracellular protein and member
of the tumor necrosis factor ligand superfamily (TNFSF), is expressed by bone marrow
plasma cells and myeloid cells, and overexpressed in multiple myeloma (MM), chronic
lymphocytic leukemia (CLL), and colorectal carcinoma. APRIL induces immune suppression
and tumor progression through the activation of BCMA- and TACI-dependent signaling
pathways.;
UNII : WM18Z62RTI;
CAS number : 2642175-46-8;
Molecule name : BION-1301;
NCI Metathesaurus CUI : CL540711;
Origin ID : C142822;
UMLS CUI : C5706632;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
