NCIt definition : The hydrochloride salt form of ivospemin, an analogue of naturally occurring polyamine
(PA), with potential antineoplastic activity. Upon subcutaneous administration, ivospemin
displaces endogenous PAs from PA-binding sites on the cell surface, which prevents
internalization of PA. This inhibits PA-dependent cell cycle processes and results
in cell cycle arrest, the induction of apoptosis, and inhibition of tumor cell proliferation.
PA uptake is upregulated in various tumor types and increased levels of PA leads to
enhanced tumor cell growth.;
Semantic type(s)