Preferred Label : Wnt Signaling Pathway Inhibitor SM08502;
NCIt definition : An orally bioavailable, small molecule inhibitor of the Wnt signaling pathway, with
potential antineoplastic activity. Upon oral administration, SM08502 inhibits the
expression of genes involved in the Wnt signaling pathway through an as of yet not
fully elucidated mechanism. This decreased expression of Wnt pathway-related genes
prevents Wnt signaling and may inhibit proliferation of cancer cells in which the
Wnt signaling pathway is overactivated. The Wnt signaling pathway is dysregulated
in many cancer cell types and plays a crucial role in tumor cell proliferation.;
Molecule name : SM-08502; SM 08502;
NCI Metathesaurus CUI : CL540726;
Origin ID : C142777;
UMLS CUI : C4684819;
Semantic type(s)
- concept_is_in_subset
