" /> Rogletimide - CISMeF





Preferred Label : Rogletimide;

NCIt related terms : Pyridoglutethimide;

NCIt definition : An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a cytochrome P450 family enzyme found in many tissues and the key enzyme in the oxidative aromatization process of androgens to estrogens. In estrogen-dependent cancers, the inhibition of aromatase by this agent leads to a reduction in the synthesis of estrogen, thereby inhibiting estrogen-mediated signal transduction and consequently reducing tumor cell growth. In addition, rogletimide also inhibits enzymes that catalyzing conversion of cholesterol to corticosteroids.;

UNII : 14P4QR28QF;

InChIKey : QXKJWHWUDVQATH-UHFFFAOYSA-N;

CAS number : 92788-10-8;

Chemical formula : C12H14N2O2;

NSC code : 619778;

Codes from synonyms : NSC0619778; 31687;

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Keyword's position in hierarchy(ies) : arborescence

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10/05/2025


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