Rogletimide - CISMeF

Preferred Label : Rogletimide;

NCIt related terms : Pyridoglutethimide;

NCIt definition : An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a cytochrome P450 family enzyme found in many tissues and the key enzyme in the oxidative aromatization process of androgens to estrogens. In estrogen-dependent cancers, the inhibition of aromatase by this agent leads to a reduction in the synthesis of estrogen, thereby inhibiting estrogen-mediated signal transduction and consequently reducing tumor cell growth. In addition, rogletimide also inhibits enzymes that catalyzing conversion of cholesterol to corticosteroids.;

UNII : 14P4QR28QF;

InChIKey : QXKJWHWUDVQATH-UHFFFAOYSA-N;

CAS number : 92788-10-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 92788-10-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C12H14N2O2;

NSC code : 619778;

Codes from synonyms : NSC0619778; 31687;

Details

Origin ID

C1427;

UMLS CUI

C0164550;

Currated CISMeF NLP mapping
- rogletimide [MeSH concept]
- rogletimide [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- rogletimide [MeSH Supplementary Concept]
- rogletimide [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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