Preferred Label : Levoketoconazole;
NCIt synonyms : Ethanone, 1-(4-(4-(((2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)-; (-)-(2S,4R)-Ketoconazole; 2S,4R Ketoconazole; Ketoconazole, (2S,4R)-; 2S,4R-Ketoconazole;
NCIt definition : An orally available levorotary enantiomer of ketoconazole with potential steroidogenesis
inhibitory activity. Following oral administration, levoketoconazole inhibits three
cytochrome P450 family enzymes involved in glucocorticoid biosynthesis, 11beta-hydroxylase
(CYP11B1), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and steroid 21-hydroxylase (CYP21A2),
which reduces the circulating levels of glucocorticoids. Therefore, this agent may
normalize the high concentration of cortisol in the blood seen in patients with Cushing
syndrome. Compared to racemic ketoconazole, the levo form is a more potent inhibitor
of glucocorticoid synthesis. Additionally, this enantiomer is less likely to inhibit
cholesterol 7alpha-hydroxylase (CYP7A1); therefore, its use may reduce the risk of
hepatoxicity. Cushing syndrome is caused by high levels of cortisol in the blood either
due to excessive production and secretion of corticosteroids, which is often the result
of adrenocorticotropic hormone (ACTH)-secreting pituitary or adrenocortical neoplasms,
or the use of synthetic corticosteroids.;
UNII : 2DJ8R0NT7K;
InChIKey : XMAYWYJOQHXEEK-ZEQKJWHPSA-N;
CAS number : 142128-57-2;
Drug name : Recorlev; NormoCort;
Molecule name : COR-003;
NCI Metathesaurus CUI : CL540161;
Origin ID : C142167;
UMLS CUI : C4550366;
Currated CISMeF NLP mapping
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
concept_is_in_subset