Preferred Label : Fascin Inhibitor NP-G2-044;
NCIt synonyms : 2-Methyl-N-(1-((4-(trifluoromethyl)phenyl)methyl)-1H-indazol-3-yl)-3-furancarboxamide;
NCIt related terms : NP-G2-044;
NCIt definition : An orally available inhibitor of the protein fascin, with potential antineoplastic
activity. Upon oral administration, NP-G2-044 targets and binds to fascin, thereby
preventing the interaction of fascin with actin filaments, thereby preventing actin
bundling and filopodia formation. By preventing actin cytoskeletal reorganization,
the dynamic changes in cell shape that are necessary for tumor cell migration and
invasion to occur are impaired, and tumor cell migration and metastasis are inhibited.
Fascin, the main actin cross-linker protein in filopodia, is upregulated in many types
of metastatic tumor cells while its expression is low or absent in normal adult epithelial
cells; its expression is correlated with aggressive phenotypes, poor prognosis, and
shorter survival. Filopodia, finger-like plasma membrane protrusions that are formed
upon remodeling of the actin cytoskeleton, are found at a high frequency in metastatic
tumor cells and their presence is correlated with tumor cell invasiveness.;
UNII : 1ER2O3UZ4W;
InChIKey : XLLRLAABUFOJPC-UHFFFAOYSA-N;
CAS number : 1807454-59-6;
Molecule name : NP-G2-044; NP G2 044;
NCI Metathesaurus CUI : CL540124;
Origin ID : C142086;
UMLS CUI : C4684394;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
