Roxadustat - CISMeF

Preferred Label : Roxadustat;

NCIt synonyms : (((4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl)amino)acetic Acid;

NCIt definition : An orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity. Upon administration, roxadustat binds to and inhibits HIF-PHI, an enzyme responsible for the degradation of transcription factors in the HIF family under normal oxygen conditions. This prevents HIF breakdown and promotes HIF activity. Increased HIF activity leads to an increase in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also reduces the expression of the peptide hormone hepcidin, improves iron availability, and boosts hemoglobin (Hb) levels. HIF regulates the expression of genes in response to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism.;

UNII : X3O30D9YMX;

InChIKey : YOZBGTLTNGAVFU-UHFFFAOYSA-N;

CAS number : 808118-40-3;

Molecule name : ASP 1517; FG-4592; FG 4592;

NCI Metathesaurus CUI : CL539495;

Details

Origin ID

C141436;

UMLS CUI

C4310578;

Currated CISMeF NLP mapping
- Roxadustat [SMS substance]
- roxadustat [MeSH concept]
- roxadustat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- roxadustat [ATC Code]
- roxadustat [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- roxadustat [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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