Preferred Label : Neoantigen-loaded Autologous Dendritic Cell Vaccine;
NCIt synonyms : Autologous Tumor Peptide-loaded Mature DC Vaccine;
NCIt definition : A personalized, peptide-based therapeutic dendritic cell (DC) vaccine consisting of
autologous DCs loaded with immunogenic peptides derived from autologous cancer cells,
with potential immunomodulating and antineoplastic activities. Upon leukapheresis,
mature DCs are loaded with immunogenic neoantigens. Vaccination with the neoantigen-loaded
autologous DC vaccine stimulates the host immune system to mount a cytotoxic T-lymphocyte
(CTL) response against tumor cells expressing the neoantigens, which results in tumor
cell lysis.;
NCI Metathesaurus CUI : CL539506;
Origin ID : C141422;
UMLS CUI : C4683806;
Semantic type(s)
- concept_is_in_subset
