Preferred Label : Eflepedocokin Alfa;
NCIt synonyms : F-652; Recombinant Human IL-22 IgG2-Fc; IL-22 Dimer F-652; IL-22 IgG2-Fc; Promenakin; Recombinant Human Interleukin-22 IgG2-Fc;
NCIt definition : A recombinant fusion protein consisting of human cytokine interleukin 22 (IL-22) fused
to a human immunoglobulin G2 (IgG2)-Fc, with potential cell protective activity. Upon
intravenous administration of eflepedocokin alfa, IL-22 binds to its cognate receptor
IL-22R, which is highly expressed in parenchymal tissues and epithelial cells at mucosal
surfaces. This leads to the activation of IL-22/IL-22R-mediated signal transduction
pathways, and results in the activation of signal transducer and activator of transcription
3 (STAT3). STAT3 activation may have a protective and regenerative effect and may
protect against the development of various inflammatory and immunological diseases.
Specifically, recombinant human IL-22 IgG2-Fc may protect intestinal stem cells from
dying due to acute graft-versus-host disease (aGvHD). IL-22, produced by various immune
cells and upregulated during inflammation, plays a key role in controlling immune
responses and bacterial infection, and in the enhancement of intestinal barrier function,
gut immunity, and tissue repair.;
UNII : ZQ9E6EX2JE;
CAS number : 1966971-51-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1966971-51-6
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G-SRS /a ;
NCI Metathesaurus CUI : CL539509;
Origin ID : C141419;
UMLS CUI : C4688441;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
