Preferred Label : PXXP Motif;
NCIt synonyms : PXXP Domain;
NCIt definition : The SH3 domain, often seen in signaling pathway proteins, frequently binds to a conserved
PXXP Motif usually found in proline-rich regions of target proteins. The SH3 domain
contains a site located between the RT and n-SRC loops that binds the PXXP motif,
which then adopts a poly-proline type II (PPII) conformation. PXXP motifs are often
clustered and have residues that contribute to binding specificity. Class I motifs
have an amino to carboxy terminal binding orientation and include sites specific for
the SRC oncoprotein. More promiscuous in their binding, Class II motifs have a carboxy
to amino terminal binding orientation, PXXP can be in either of two positions, and
they have basic residues at the C-terminus. (NCI);
Origin ID : C14110;
UMLS CUI : C1518834;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
