KH Domain - CISMeF

Preferred Label : KH Domain;

NCIt synonyms : K Homology Domain;

NCIt definition : First identified in human hnRNPK protein, the conserved KH Domain of around 45-70 amino acids is present in a variety of nucleic acid-binding proteins. The domain may bind RNA in vivo. KH motifs are found in one or multiple copies, interspersed with RGG repeats, that may function cooperatively or, in single motif proteins, independently. KH domains can be separated into two groups: type-1 (beta-alpha-alpha-beta-beta-alpha) and type-2 (alpha-beta-beta-alpha-alpha-beta). The VIGXXGXXI sequence is preserved in the RNA binding motif between helix 1 and 2 (type-1) and helix 2 and 3 (type-2). The beta sheets are supported by alpha helixes. (NCI);

Details

Origin ID

C14092;

UMLS CUI

C1517645;

Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
is_structural_domain_or_motif_of_gene_product
- Exosome Complex Component RRP40 [NCIt concept]
- Far Upstream Element-Binding Protein 1 [NCIt concept]
- Fragile X Mental Retardation Protein 1 [NCIt concept]
- Heterogeneous Nuclear Ribonucleoprotein K [NCIt concept]
- KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 1 [NCIt concept]
- KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 3 [NCIt concept]
- Poly(rC)-Binding Protein 1 [NCIt concept]
- Protein Bicaudal C Homolog 1 [NCIt concept]
- Protein Quaking [NCIt concept]
- RNA-Binding Protein Nova-1 [NCIt concept]
- RNA-Binding Protein Nova-2 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients