Preferred Label : RHO Effector Domain;
NCIt synonyms : HR1 Domain; Hr1 Repeat; REM Repeat;
NCIt definition : The REM repeat, which is also called rho effector or HR1 domain, was first described
as a three times repeated homology region of the N-terminal non-catalytic part of
protein kinase PRK1(PKN). The first two of these repeats were later shown to bind
the small G protein rho known to activate PKN in its GTP-bound form. Similar rho-binding
domains also occur in a number of other protein kinases and in the rho-binding proteins
rhophilin and rhotekin. Recently, the structure of the N-terminal REM repeat complexed
with RhoA has been determined by X-ray crystallography. It forms an antiparallel coiled-coil
fold termed an ACC finger.;
Origin ID : C14078;
UMLS CUI : C1514650;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
