Clinical Stage IV Retinoblastoma AJCC v8NCIt concept
Preferred Label : Clinical Stage IV Retinoblastoma AJCC v8;
NCIt definition : Stage IV includes: Any cT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without
microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX:
Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal
RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral
retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor
(i.e., trilateral retinoblastoma), patient with family history of retinoblastoma,
or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.);