Clinical Stage II Retinoblastoma AJCC v8NCIt concept
Preferred Label : Clinical Stage II Retinoblastoma AJCC v8;
NCIt definition : Stage II includes: cT4a, cN0, cM0, Any H. cT4a: Radiologic evidence of retrobulbar
optic nerve involvement or thickening of optic nerve or involvement of orbital tissues.
cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial
or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1
gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity
assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive
neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history
of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation.
(AJCC 8th ed.);