Preferred Label : Carbon C 14-AC0010;
NCIt synonyms : 14C-AC0010; [14C] AC0010; 14C-labeled AC0010;
NCIt definition : A radioconjugate composed of AC0010, an orally available, third generation, selective
inhibitor of mutant forms of the epidermal growth factor receptor (EGFR), including
the second-site resistance mutation T790M, that is labeled with the radioisotope carbon
C 14, with potential use in evaluating the pharmacokinetic profile of AC0010. Upon
administration, the AC0010 moiety specifically and irreversibly binds to and inhibits
the activity of mutant forms of EGFR. Labeling of AC0010 with the radioactive tracer
carbon C 14 allows for the evaluation of AC0010's pharmacokinetic profile, including
its absorption, distribution, metabolism, and excretion (ADME).;
NCI Metathesaurus CUI : CL538615;
Origin ID : C140555;
UMLS CUI : C4683046;
Semantic type(s)
- concept_is_in_subset
