Preferred Label : Retinoid X Receptor Agonist IRX4204;
NCIt synonyms : RXR Agonist IRX4204;
NCIt definition : A second generation rexinoid and agonist of retinoid X receptor (RXR), with potential
antineoplastic, neuroprotective, immunoregulatory, and disease-modifying activities.
Upon administration, IRX4204 specifically binds to and activates RXRs, thereby activating
RXR-mediated signaling pathways and inducing changes in gene expression that lead
to cell differentiation. In responsive cancer cells, IRX4204 induces cell differentiation,
decreases cell proliferation, and induces apoptosis, which leads to cancer regression.
IRX4204 enhances the differentiation of CD4-positive T lymphocytes into inducible
regulatory T cells (iTreg) and suppresses the development of inflammatory T helper
17 (Th17) cells. In addition, IRX4204 is able to cross the blood-brain barrier (BBB)
and induces the differentiation of oligodendrocyte precursor cells (OPCs) into oligodendrocytes,
promotes repair of myelin, and enhances the survival of dopaminergic neurons.;
Molecule name : IRX-4204; AGN194204; IRX 4204;
NCI Metathesaurus CUI : CL538619;
Origin ID : C140551;
UMLS CUI : C4310044;
Currated CISMeF NLP mapping
- IRX4204 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- IRX4204 [MeSH Supplementary Concept]
- concept_is_in_subset
