Preferred Label : Walker-A Motif;
NCIt synonyms : Walker-A Domain;
NCIt definition : The ATP binding cassette (ABC) is the largest protein family known and many of its
members are membrane proteins (ABC transporters) active in the transport of a wide
variety of substances across membranes. ABC proteins are identified by the presence
of one or two cytosolically oriented ATP-binding cassettes or nucleotide-binding domains
(NBD) of about 200 amino acid residues. Each NBD contains three typical motifs: the
Walker A motif, GX4GK(ST), the Walker B motif and the ABC signature or C motif. Walker
A and B motifs are found in other nucleotide-binding proteins, including P-, F- and
V-ATPases, G proteins, adenylate kinase, myosin, phosphofructokinase and ATP/ADP exchangers.
Although the overall similarity between ABC proteins can be very low, their NBDs share
an average of 30-40 % similarity.;
Origin ID : C14043;
UMLS CUI : C1520118;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
