Preferred Label : Modakafusp Alfa;
NCIt synonyms : CD38-targeted IgG4 Fused with Attenuated IFNa; Anti-CD38-targeted IgG4-attenuated Interferon Alpha TAK-573;
NCIt related terms : Anti-CD38-targeted IgG4-attenuated IFNa TAK-573;
NCIt definition : A proprietary preparation composed of an immunoglobulin G4 (IgG4) directed against
the cell surface glycoprotein CD-38 (CD38) that is fused to an attenuated form of
human interferon alpha (IFN alpha; IFNa), with potential immunomodulating and antineoplastic
activities. Upon administration, modakafusp alfa specifically targets and binds to
CD38 on CD38-positive tumor cells. In turn, the IFNa moiety binds to cell-surface
IFN receptors, and activates IFN-mediated signal transduction pathways, which results
in the transcription and translation of genes whose products may cause antiproliferative
effects in CD38-positive tumor cells. CD38, a type II transmembrane glycoprotein,
is present on various immune cells and hematologic malignancies, and its expression
has been correlated with poor prognosis.;
UNII : TN8CEX4UT2;
CAS number : 2254522-19-3;
Molecule name : TEV-48573; TAK-573;
NCI Metathesaurus CUI : CL538488;
Origin ID : C140427;
UMLS CUI : C5418196;
Semantic type(s)
- concept_is_in_subset
- has_target
