Preferred Label : Copper 64 Cu-DOTA-daratumumab;
NCIt synonyms : Copper Cu 64 Daratumumab; 64Cu-DOTA-daratumumab;
NCIt definition : A radioimmunoconjugate containing daratumumab, a human immunoglobulin G1 kappa (IgG1k)
monoclonal antibody directed against the cell surface glycoprotein CD38, conjugated
with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic
acid (DOTA), and labeled with the radioisotope copper Cu 64, with potential diagnostic
properties upon positron emission tomography (PET) imaging. The monoclonal antibody
moiety of copper Cu 64-DOTA-daratumumab specifically targets and binds to cell surface
antigen CD38. Upon binding, the radioisotope moiety may be detected using PET, thereby
allowing the imaging and quantification of CD38-expressing tumor cells. CD38, a cell
surface glycoprotein, is expressed on various hematopoietic cells and is overexpressed
on multiple myeloma (MM) cells.;
NCI Metathesaurus CUI : CL538419;
Origin ID : C140353;
UMLS CUI : C4682888;
Semantic type(s)
- concept_is_in_subset
- has_target
