Preferred Label : Piperazinedione;
NCIt synonyms : PZD dihydrochloride, 3,6-bis(5-chloro-2-piperidinyl)-, dihydrochloride; PZD; Compound 593A; Merck Compound 593A; 2,5-piperazinedione, 3, 6-bis(5-chloro-2-piperidinyl)-, dihydrochloride, [3S-[3alpha(2S*,5R*),6alpha(2S*,5R*)]]-
(9CI);
NCIt related terms : 2, 5-Piperazinedione, 3,6-bis-(5-chloro-2-piperidyl)-, dihydrochloride; 2,5-Piperazinedione, 3, 6-bis(5-chloro-2-piperidinyl)-, dihydrochloride, [3S-[3.alpha.(2S*,5R*),6.alpha.(2S*,5R*)]]-
(9CI); 593A;
NCIt definition : A crystalline antibiotic fermentation product isolated from the bacterium Streptomyces
griseoluteus with antineoplastic activity. Piperazinedione alkylates DNA at the N-7
position of guanine, inhibiting DNA replication and inducing cell cycle arrest.;
CAS number : 41109-80-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 41109-80-2
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G-SRS /a ;
Molecule name : 593A;
NSC code : 135758;
Codes from synonyms : NSC0135758;
Origin ID : C1401;
UMLS CUI : C0137098;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
