Preferred Label : Isavuconazonium Sulfate;
NCIt synonyms : 1-((2R,3R)-3-(4-(4-Cyanophenyl)-1,3-thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-((1RS)-1-((methyl(3-((((methylamino)acetyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium
Monosulfate; Glycine, N-methyl-, (2-(((1-(1-((2R,3R)-3-(4-(4-cyanophenyl)-2-thiazolyl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4H-1,2,4-triazolium-4-yl)ethoxy)carbonyl)methylamino)-3-pyridinyl)methyl
Ester, Sulfate (1:1);
NCIt related terms : Cresemba;
NCIt definition : The sulfate ester form of isavuconazonium, a prodrug of the triazole antifungal agent
isavuconazole, with broad-spectrum antifungal activity. Upon administration, isavuconazonium
sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole.
Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol
14-alpha-demethylase (CYP51), which catalyzes the demethylation of lanosterol to yield
ergosterol, an important component of the fungal cell membrane. Inhibition of CYP51
leads to a decrease in fungal ergosterol production and disrupts synthesis of the
fungal cell membrane, which decreases membrane integrity, increases cell membrane
permeability and promotes the loss of essential intracellular elements. This results
in fungal cell lysis and death.;
UNII : 31Q44514JV;
InChIKey : LWXUIUUOMSMZKJ-KLFWAVJMSA-M;
CAS number : 946075-13-4;
Drug name : Cresemba;
Molecule name : BAL8557-002;
Origin ID : C139756;
UMLS CUI : C4018470;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
