NCIt synonyms : Stage IV Vulvar Carcinoma AJCC v8;
NCIt related terms : Stage IV Vulvar Cancer;
NCIt definition : Stage IV includes: T1-T3, N3, M0-M1. T1: Tumor confined to the vulva and/or perineum.
Multifocal lesions should be designated as such. The largest lesion or the lesion
with the greatest depth of invasion will be the target lesion identified to address
the highest pT stage. Depth of invasion is defined as the measurement of the tumor
from the epithelial-stromal junction of the adjacent most superficial dermal papilla
to the deepest point of invasion. T2: Tumor of any size with extension to adjacent
perineal structures (lower/distal third of the urethra, lower/distal third of the
vagina, anal involvement). T3: Tumor of any size with extension to any of the following:
upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina,
bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated
regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis
(including pelvic lymph node metastasis). (from AJCC 8th Ed.);