Preferred Label : Prognostic Stage IIIC Breast Cancer AJCC v8;
NCIt synonyms : Prognostic Stage IIIC Breast Carcinoma AJCC v8;
NCIt related terms : Stage IIIC Breast Cancer;
NCIt definition : Stage IIIC includes: (T2, N1, M0, G3, HER2 Status: Negative, ER Status: Negative,
PR Status: Any); (T3, N0, M0, G3, HER2 Status: Negative, ER Status: Negative, PR Status:
Any ); (T0-2, N2, M0, G2, HER2 Status: Negative, ER Status: Negative, PR Status: Negative);
(T0-2, N2, M0, G3, HER2 Status: Negative, ER Status: Positive, PR Status: Negative);
(T0-2, N2, M0, G3, HER2 Status: Negative, ER Status: Negative, PR Status: Any); (T3,
N1-2, M0, G2, HER2 Status: Negative, ER Status: Negative, PR Status: Negative); (T3,
N1-2, M0, G3, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T3,
N1-2, M0, G3, HER2 Status: Negative, ER Status: Negative, PR Status: Any); (T4, N0-2,
M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T4, N0-2,
M0, G1, HER2 Status: Negative, ER Status: Negative, PR Status: Any); (T4, N0-2, M0,
G2, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T4, N0-2, M0,
G2, HER2 Status: Positive, ER Status: Negative, PR Status: Any); (T4, N0-2, M0, G2,
HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T4, N0-2, M0, G2,
HER2 Status: Negative, ER Status: Negative, PR Status: Any); (T4, N0-2, M0, G3, HER2
Status: Positive, ER Status: Positive, PR Status: Negative); (T4, N0-2, M0, G3, HER2
Status: Positive, ER Status: Negative, PR Status: Any); (T4, N0-2, M0, G3, HER2 Status:
Negative, ER Status: Any, PR Status: Any); (Any T, N3, M0, G1, HER2 Status: Negative,
ER Status: Positive, PR Status: Negative); (Any T, N3, M0, G1, HER2 Status: Negative,
ER Status: Negative, PR Status: Any); (Any T, N3, M0, G2, HER2 Status: Positive, ER
Status: Positive, PR Status: Negative); (Any T, N3, M0, G2, HER2 Status: Positive,
ER Status: Negative, PR Status: Any); (Any T, N3, M0, G2, HER2 Status: Negative, ER
Status: Positive, PR Status: Negative); (Any T, N3, M0, G2, HER2 Status: Negative,
ER Status: Negative, PR Status: Any); (Any T, N3, M0, G3, HER2 Status: Positive, ER
Status: Positive, PR Status: Negative); (Any T, N3, M0, G3, HER2 Status: Positive,
ER Status: Negative, PR Status: Any); (Any T, N3, M0, G3, HER2 Status: Negative, ER
Status: Any, PR Status: Any). T0: No evidence of primary tumor. T1: Tumor measuring
20 mm or less in greatest dimension. T2: Tumor measuring more than 20 mm, but not
more than 50 mm in greatest dimension. T3: Tumor measuring more than 50 mm in greatest
dimension. T4: Tumor of any size with direct extension to the chest wall and/or to
the skin (ulceration or macroscopic nodules); invasion of the dermis alone does not
qualify as T4. N0: No regional lymph node metastasis is identified or isolated tumor
cell clusters (ITCs) are identified only. N1: Tumor with micrometastases; or metastases
in 1-3 axillary lymph nodes; and/or clinically negative internal mammary nodes with
micrometastases or macrometastases by sentinel lymph node biopsy. N2: Tumor with metastases
in 4-9 axillary lymph nodes; or positive ipsilateral internal mammary lymph nodes
by imaging in the absence of axillary lymph node metastases. N3: Tumor with metastases
in 10 or more axillary lymph nodes; or in infraclavicular (level III axillary) lymph
nodes; or positive ipsilateral internal mammary lymph nodes by imaging in the presence
of one or more positive level I, II axillary lymph nodes; or in more than three axillary
lymph nodes and micrometastases or macrometastases by sentinel lymph node biopsy in
clinically negative ipsilateral internal mammary lymph nodes; or in ipsilateral supraclavicular
lymph nodes. G1: Low combined histologic grade (favorable); SBR score of 3-5 points.
G2: Intermediate combined histologic grade (moderately favorable); SBR score: 6-7
points. G3: High combined histologic grade (unfavorable); SBR score of 8-9 points.
M0: No clinical or radiographic evidence of distant metastases. Imaging studies are
not required to assign the M0 category. (AJCC 8th ed.);
Neoplastic status : Malignant;
NCI Metathesaurus CUI : CL526880;
Origin ID : C139585;
UMLS CUI : C4528591;
- Disease excludes abnormal cell
- Has associated anatomic sites
- Semantic type(s)
- concept_is_in_subset
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_is_stage