Preferred Label : Oncolytic HSV-1 rQNestin34.5v.2;
NCIt synonyms : Oncolytic rQNestin34.5v.2; Oncolytic rQNestin34.5v.2 HSV Virus; rQNestin34.5v.2; Genetically Engineered HSV-1 Virus rQNestin34.5v.2;
NCIt definition : A neuroattenuated, replication-competent, recombinant and genetically-engineered herpes
simplex virus type 1 (HSV-1), with potential oncolytic and immunostimulating activities.
In rQNestin34.5v.2, the UL39 gene encoding for the viral ribonucleotide reductase
large subunit infected cell protein 6 (ICP6) and both endogenous copies of the gamma34.5
gene that encodes for the RL1 neurovirulence protein infected cell protein 34.5 (ICP34.5),
which is needed for robust viral growth in an infected cell, are deleted, and one
copy of the gamma34.5 gene is reinserted under control of a nestin promoter, which
is selectively activated in gliomas. Upon intratumoral administration, oncolytic HSV-1
rQNestin34.5v.2 preferentially infects and replicates within the rapidly dividing,
glioma cells, thereby directly lysing tumor cells. The released virus particles, in
turn, infect and replicate in neighboring tumor cells, thereby further killing tumor
cells. rQNestin34.5v.2 also elicits a tumor-specific systemic immune and cytotoxic
T-lymphocyte (CTL) response, thereby killing nearby non-infected tumor cells. By inactivating
UL39, viral ribonucleotide reductase activity is disrupted, resulting in the inhibition
of nucleotide metabolism and viral DNA synthesis in non-dividing, healthy cells but
not in dividing cells. Glioma-selective expression of ICP34.5 imparts tumor selectivity
by preventing replication in healthy cells.;
NCI Metathesaurus CUI : CL526908;
Origin ID : C139551;
UMLS CUI : C4528567;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
