NCIt related terms : L-MTP-PE; MEPACT; muramyl tripeptide phosphatidylethanolamine;
NCIt definition : A liposomal formulation containing a muramyl dipeptide (MDP) analogue with potential
immunomodulatory and antineoplastic activities. Muramyl tripeptide phosphatidylethanolamine
(MTP-PE), a derivative of the mycobacterial cell wall component MDP, activates both
monocytes and macrophages. Activated macrophages secrete cytokines and induce the
recruitment and activation of other immune cells, which may result in indirect tumoricidal
effects. Liposomal encapsulation of MTP-PE prolongs its half-life and enhances tissue
targeting.;
Alternative definition : NCI-GLOSS: A drug being studied in the treatment of young adults with bone cancer
that has gotten worse or come back. L-MTP-PE activates certain types of white blood
cells and helps the immune system kill cancer cells. It is a type of immunostimulant.;
UNII : 1LM890Q4FY;
InChIKey : NGIYLSFJGRLEMI-MHTUOZSYSA-M;
CAS number : 838853-48-8;
Drug name : Mepact; Junovan;
Molecule name : CGP 19835A Lipid;
Chemical formula : C59H108N6O19P.Na.H2O;
NSC code : 628280;
Codes from synonyms : CDR0000644755; CDR0000644756; CDR0000644757; CDR0000644758; 120531;