" /> Merbarone - CISMeF





Preferred Label : Merbarone;

NCIt definition : A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes with DNA replication via binding directly to topoisomerase II at a domain that maybe shared by other topoisomerase II cleavage-enhancing agents, ex., etoposide. Its mechanism of action appears to be a novel one, since merbarone does not intercalate DNA nor stabilize DNA-topoisomerase II cleavable complexes.;

UNII : YWB9IF596V;

CAS number : 97534-21-9;

NSC code : 336628;

Codes from synonyms : NSC0336628;

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28/07/2025


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