NCIt definition : A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase
II inhibitor with antineoplastic activity. Merbarone interferes with DNA replication
via binding directly to topoisomerase II at a domain that maybe shared by other topoisomerase
II cleavage-enhancing agents, ex., etoposide. Its mechanism of action appears to be
a novel one, since merbarone does not intercalate DNA nor stabilize DNA-topoisomerase
II cleavable complexes.;
UNII : YWB9IF596V;
CAS number : 97534-21-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 97534-21-9
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