Merbarone - CISMeF

Preferred Label : Merbarone;

NCIt definition : A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes with DNA replication via binding directly to topoisomerase II at a domain that maybe shared by other topoisomerase II cleavage-enhancing agents, ex., etoposide. Its mechanism of action appears to be a novel one, since merbarone does not intercalate DNA nor stabilize DNA-topoisomerase II cleavable complexes.;

UNII : YWB9IF596V;

CAS number : 97534-21-9;

NSC code : 336628;

Codes from synonyms : NSC0336628;

Details

Origin ID

C1390;

UMLS CUI

C0127565;

Currated CISMeF NLP mapping
- merbarone [MeSH concept]
- merbarone [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- merbarone [MeSH concept]
- merbarone [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Filgrastim/Merbarone [NCIt concept]

Keyword's position in hierarchy(ies) :

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