Preferred Label : Liposomal NDDP;
NCIt synonyms : Liposomal-Cisplatin Analogue; Liposomal Neodecanoic Acid Platinum Complex; Liposomal-Entrapped Cis-Bis-Neodecanoate-trans-R,R-1,2-Diaminocyclohexane Platinum
(II); L-NDDP;
NCIt related terms : AROPLATIN;
NCIt definition : A synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum
(NDDP), a third-generation platinum complex analogue of cisplatin, with potential
antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving
groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly
reactive and alkylate macromolecules, forming both inter- and intra-stranded DNA cross-linkings
and inhibiting DNA synthesis, which results in tumor cell cytotoxicity. Because DNA
mismatch-repair (MMR) complexes do not recognize DACH-platinum adducts, DNA repair
mechanisms are inhibited, overcoming limitations observed with other platinum-based
agents. In addition, the liposomal encapsulation improves the bioavailability of NDDP
and reduces its toxicity profile.;
UNII : J7M4Z2D183;
Drug name : Aroplatin;
Origin ID : C1383;
UMLS CUI : C0125061;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
