Preferred Label : K 252a;
NCIt synonyms : Antibiotic K 252A; Protein Kinase Inhibitor K252a; Antibiotic SF 2370; 9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic
acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-;
NCIt related terms : K252A;
NCIt definition : An indolocarbazole-based alkaloid and staurosporine analog isolated from Nocardiopsis
and Actinomadura species, with kinase inhibiting activity. K252a inhibits a wide variety
of enzymes, including, but not limited to, protein kinase A (PKA), C (PKC) and G (PKG),
calcium (Ca2 )/calmodulin-dependent kinase type II (CaMKII), phosphorylase kinase
(PhK), tropomyosin receptor kinase (Trk; neurotrophic tyrosine receptor kinase; NTRK),
myosin light-chain kinase (MLCK; MYLK), mixed-lineage protein kinase 3 (MLK3), receptor-type
tyrosine-protein kinase FLT3 (CD135; fms-like tyrosine kinase 3; fetal liver kinase-2;
FLK2) and actin-regulating kinase PRK1 (PAK1). Inhibition of these kinases prevents
the activation of signaling pathways in which these kinases play a key role.;
UNII : IV7H45AM5B;
InChIKey : KOZFSFOOLUUIGY-SOLYNIJKSA-N;
CAS number : 99533-80-9;
Molecule name : K-252a; K 252a; SF 2370;
Chemical formula : C27H21N3O5;
Origin ID : C1382;
UMLS CUI : C0124355;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
