Neoantigen DNA-Based Pancreatic Cancer Vaccine

Preferred Label : Neoantigen DNA-Based Pancreatic Cancer Vaccine;

NCIt synonyms : Personalized Neoantigen DNA Pancreatic Cancer Vaccine; Neoantigen DNA Pancreatic Cancer Vaccine;

NCIt definition : A personalized, polyepitope DNA vaccine composed of a DNA plasmid encoding multiple, highly immunogenic tumor associated antigens (TAAs) that are specifically expressed by a patient's pancreatic cancer cells, including personalized epitopes of the TAA mesothelin, with potential immunostimulatory and antineoplastic activities. Upon intramuscular administration and electroporation of the neoantigen DNA-based pancreatic cancer vaccine, the expressed TAAs induce a specific cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing the neoantigens.;

NCI Metathesaurus CUI : CL525668;

Details

Origin ID

C138149;

UMLS CUI

C4527403;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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