Preferred Label : Rolinsatamab Talirine;
NCIt synonyms : ADC ABBV-176;
NCIt definition : An antibody-drug conjugate (ADC) composed of a proprietary monoclonal antibody against
the prolactin receptor (PRLR) linked to an as of yet undisclosed cytotoxic agent,
with potential antineoplastic activity. Upon intravenous administration of rolinsatamab
talirine, rolinsatamab targets and binds to PRLR expressed on tumor cells. Upon binding
and internalization, talirine is released and kills the PRLR-expressing tumor cells,
through an as of yet unknown mechanism of action. PRLR, a tumor-associated antigen
(TAA), is overexpressed by a variety of tumor cell types.;
UNII : 25TA76U16O;
CAS number : 2095467-44-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2095467-44-8
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G-SRS /a ;
Molecule name : ABBV-176; ABBV 176;
NCI Metathesaurus CUI : CL525031;
Origin ID : C137991;
UMLS CUI : C5418192;
Semantic type(s)
- concept_is_in_subset
