Preferred Label : Personalized Live-attenuated Double-deleted Listeria monocytogenes;
NCIt synonyms : Patient-specific LADD; Personalized LADD; pLADD;
NCIt definition : A proprietary, personalized live, attenuated, double-deleted (pLADD) strain of the
Gram-positive bacterium Listeria monocytogenes encoding multiple, patient-specific
neoantigens, with potential immunostimulatory and antineoplastic activities. Upon
intravenous administration, the tumor-associated antigens (TAAs) expressed in pLADD
are taken up by antigen-presenting cells (APCs), including dendritic cells (DCs),
and are processed and presented to the immune system by both major histocompatibility
complex (MHC) class I and II molecules. This activates the immune system and leads
to both an innate immune response and the recruitment and activation of tumor-specific
cytotoxic T-lymphocytes (CTLs) against the TAAs specifically expressed by the patient's
tumor cells, which eventually results in tumor cell lysis.;
NCI Metathesaurus CUI : CL524895;
Origin ID : C137823;
UMLS CUI : C4527231;
Semantic type(s)
- concept_is_in_subset
