Preferred Label : Protease Inhibitor Formulation LB1148;
NCIt definition : A proprietary formulation comprised of the serine protease inhibitor tranexamic acid
(TXA), polyethylene glycol (PEG), electrolytes, and sugar, with potential GI protective
activity. After reconstitution in water and upon oral or enteral administration before
abdominal surgery, TXA in the protease inhibitor formulation LB1148 targets and inhibits
several serine proteases in the gastrointestinal (GI) tract, thereby preventing and
protecting the intestinal mucosa against degradation, which preserves gastrointestinal
(GI) integrity, function and motility. By inhibiting digestive proteases, the intestinal
mucosal barrier is preserved during acute physiologic shock, which may prevent multi-organ
failure, postoperative ileus and surgical intra-abdominal adhesions. PEG enhances
transport of TXA through the GI tract. The other components provide energy and balance
dietary electrolytes, thereby promoting healing of the GI barrier.;
Molecule name : LB-1148;
NCI Metathesaurus CUI : CL524832;
Origin ID : C137683;
UMLS CUI : C4527194;
Semantic type(s)
- concept_is_in_subset
