Preferred Label : LMP1-specific Chimeric Antigen Receptor-expressing T Lymphocytes;
NCIt synonyms : LMP1-CAR-CTLs; LMP1-CAR-T Cells; Anti-LMP1 CAR T Cells;
NCIt definition : A preparation of cytotoxic T-lymphocytes (CTL) transfected with a chimeric antigen
receptor (CAR) specifically recognizing the Epstein-Barr virus (EBV) latent membrane
protein 1 (LMP1; LMP-1), with potential antineoplastic activity. Upon administration
of the LMP1-specific CAR-expressing T lymphocytes to patients with LMP1-positive tumors,
the CTLs specifically target and lyse tumor cells expressing LMP1, thereby inhibiting
tumor cell proliferation. The tumor-associated antigen (TAA) LMP1 is expressed in
various malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma.;
NCI Metathesaurus CUI : CL524744;
Origin ID : C136986;
UMLS CUI : C4527157;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
