Preferred Label : Obrindatamab;
NCIt synonyms : DART Protein MGD009; B7-H3 x CD3 DART Protein; B7-H3 x CD3 Dual-affinity Re-targeting Protein MGD009; Dual-affinity B7-H3/CD3-targeted Protein MGD009;
NCIt definition : An Fc-bearing humanized bispecific dual-affinity re-targeting (DART) protein composed
of Fv regions derived from monoclonal antibodies against the immunoregulatory protein
B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential immunostimulating
and antineoplastic activities. Upon administration of obrindatamab, the anti-B7-H3
component targets and binds to the cell surface antigen B7-H3; at the same time, the
anti-CD3 component binds to human CD3. This cross-links the T-cells to B7-H3-expressing
tumor cells, activates and redirects endogenous T-cells to kill B7-H3-expressing tumor
cells, and inhibits proliferation of B7-H3-expressing tumor cells. B7-H3, a type I
transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is
overexpressed on certain tumor cell types and on various immune cells but is minimally
expressed by normal human tissues. B7-H3 is a negative regulator of T-cell activation
and its overexpression plays a key role in immuno-evasion, tumor cell invasion and
metastasis, and its expression is correlated with poor prognosis.;
UNII : YE8XXF1SDZ;
CAS number : 2069959-72-2;
Molecule name : MGD-009; MGD 009;
NCI Metathesaurus CUI : CL524772;
Origin ID : C136983;
UMLS CUI : C5446310;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
