Preferred Label : Small Cell Lung Carcinoma Transformation;
NCIt synonyms : Lung Adenocarcinoma Transformation; SCLC Transformation;
NCIt definition : A term that usually refers to the histological transformation of EGFR mutation-positive
lung non-small cell carcinoma to small cell carcinoma in response to treatment with
tyrosine kinase inhibitors, resulting in resistance to first-line tyrosine kinase
inhibitors. It may also refer to rare cases of lung adenocarcinoma carrying KRAS G12C
mutation that are transformed into small cell carcinoma before treatment.;
NCI Metathesaurus CUI : CL524468;
Origin ID : C136624;
UMLS CUI : C4526833;
Semantic type(s)
- concept_is_in_subset
