Doxorubicin-HPMA Conjugate

Preferred Label : Doxorubicin-HPMA Conjugate;

NCIt synonyms : Doxorubicin-HPMA Copolymer Conjugate; Doxorubicin-HPMA; HPMA-Doxorubicin; P(GFLG)-ADR;

NCIt definition : A copolymer conjugate of the antineoplastic anthracycline doxorubicin and the water-soluble polymer N-(2-hydroxypropyl) methacrylamide (HPMA). Doxorubicin, an intercalator and a topoisomerase II inhibitor, prevents DNA replication and ultimately inhibits protein synthesis. This agent also generates oxygen free radicals, resulting in cytotoxic lipid peroxidation of cell membrane lipid. HPMA conjugation enhances the permeability and retention of this agent within the tumor vasculature. Poorly cleared by the lymphatic system, this formulation undergoes increased cleavage by tumor cell lysosomal proteinases, resulting in increased, sustained intracellular concentrations of free doxorubicin. Compared to other doxorubicin-containing formulations, this formulation may exhibit an improved toxicity profile due to the lower concentrations of free doxorubicin to which non-malignant tissues are exposed.;

Molecule name : PK1;

Details

Origin ID

C1366;

UMLS CUI

C0114882;

Automatic exact mappings (from CISMeF team)
- doxorubicin-N-(2-hydroxypropyl)methacrylamide copolymer conjugate [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- doxorubicin-HPMA conjugate [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- doxorubicin-HPMA conjugate [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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