Ravtansine - CISMeF

Preferred Label : Ravtansine;

NCIt synonyms : N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine; N2'-[4-[(3-carboxypropyl)dithio]-4-methyl-1-oxo-2-sulfopentyl]-N2'-deacetylmaytansine;

NCIt related terms : DM4;

NCIt definition : A tubulin-binding maytansinoid. Ravtansine binds to tubulin at the maytansine-binding site, which disrupts microtubule assembly/disassembly dynamics and inhibits mitosis.;

UNII : WOB38VS2NI;

CAS number : 796073-69-3;

Molecule name : DM 4; DM-4;

Details

Origin ID

C136538;

UMLS CUI

C4505404;

Automatic exact mappings (from CISMeF team)
- maytansine [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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