Preferred Label : Dimesna;
NCIt synonyms : Mesna Disulfide; 2,2'-Dithiobisethanesulfonic Acid, Disodium Salt; 2,2'-Dithio-bis-ethanesulfonate, Disodium Salt;
NCIt definition : The disodium salt form of dithio-ethane sulfonate, a dimer of mesna and a disulfide
bond disrupting agent (DDA), with uroprotective, nephroprotective, chemoprotective,
chemosensitizing and chemo-enhancing activities. Upon administration, dimesna is able
to modify cysteine on various proteins, such as the kinases EGFR, MET and ROS1, thereby
disrupting extracellular disulfide bonds and modulating the activity of these proteins.
This inhibits their signaling pathways and downregulates proliferative signaling in
cancer cells in which these kinases are overexpressed. This may also enhance the activity
of other kinase inhibitors targeting the same proteins. In the kidneys, dimesna undergoes
reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic
ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification.
This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis. In addition,
dimesna reduces toxicities associated with taxanes and platinum-based chemotherapeutic
agents.;
Alternative definition : NCI-GLOSS: A drug that belongs to the family of drugs called chemoprotective agents.;
UNII : 230R951Y4D;
InChIKey : KQYGMURBTJPBPQ-UHFFFAOYSA-L;
CAS number : 16208-51-8;
Drug name : Tavocept;
Molecule name : BNP7787; LP 300; LP-300;
Chemical formula : C4H8O6S4.2Na;
NSC code : 716976;
Codes from synonyms : NSC0716976; CDR0000046116; 05279;
Origin ID : C1365;
UMLS CUI : C0114346;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
